Programme




* Disclaimer: All are subject to change

 

Pre-Conference Workshop (7th December 2021)

0800

Registration

0900

Details of the Workshop

Online Platform

0900

a) Big Data: Principle Component Analysis (PCA) & Partial Least Square (PLS) Analysis using SIMCA: a-hands-on approach
Demonstrators/Speakers:
– Assoc. Prof. Dr. Baharudin Ibrahim (UM)
– Dr. Fatimatuzzahra Abdul Aziz (USM)
– Mr. Abdulkader Ahmad Bawadikji (USM)
>> Click for more information

Zoom

0900

b) Conducting a Pharmacometric-Based Study
Demonstrators/Speakers:
– Dr. Hadzliana Zainal (USM)
– Dr. Sabariah Noor Harun (USM)
– Dr Siti Maisharah Sheikh Ghadzi (USM)
>> Click for more information

Zoom

0900

c) A Painless Way of Analysing Next-Generation Sequencing Data
Demonstrators/Speakers:
– Dr. Chua Eng Wee (UKM)
– Dr. Norfarhan Bt Mohd Assa`Ad (UKM)
– Dr. Shairah Bt Abdul Razak (UKM)
>> Click for more information

Zoom

0900

d) Stem Cell-Based Therapy
Demonstrators/Speakers:
– Dr. Ren Xi (Charlie) (Cernegie Mellon University)
– Dr. Kenji Miki (Havard Medical School)
– Dr. Aizizah Ab. Ghani (MOH)
– Mr. Chew Chun Keat (MOH)
– Dr. Zou Yu (Thermo Fisher)
– Dr. Xie Wei (Thermo Fisher)
>> Click for more information

Webex

0900

e) CRISPR-Cas9 Gene Editing Technology
Demonstrators/Speakers:
– Dr. Saiful Effendi Syafruddin (UKM)
– Dr. Mohamad Aimanuddin Mohtar (UKM)
>> Click for more information

Zoom

1030

Short Break

1045

Workshops Resume

1300

Lunch Break

1400

Workshops Resume

1600

Workshops End



 

Conference Day 1 (8th December 2021)

0800

Registration

0830

Welcome & Opening Address

AREA 1: CANCER

0840

Plenary Talk 1 (30 min without Q&A)
Title: Harnessing Digital Medicine to Optimise Drug Development and N-of-1 Healthcare
Prof. Dr. Dean Ho
(NUS, Singapore)
Moderator: Prof. Dr. Johnson Stanslas

0910

Invited Talk 1 (20 min)
Title: Targeting KRAS with small-molecule non-covalent inhibitors
Prof. Dr. Alemayehu Gorfe
(University of Texas, USA)
Moderator: Assoc. Prof. Dr. Lim Siong Meng

0930

Screen Break (5 min)

SPECIAL TOPIC: Covid-19

0935

Plenary Talk 2 (30 min without Q&A)
Title: COVID 19 Vaccines: current state of the art
Dr. Richard M. Novak
(University of Illinois Hospital, USA)
Moderator: Dr. How Kang Nien

1005

Invited Talk 2 (20 min)
Title: Mapping the spatiotemporal complexity of glioblastoma tumors
Assoc. Prof. Dr. Carol Tang
(NNI, Singapore)
Moderator: Dr. Jonathan Lim Chee Woei

1025

Invited Talk 3 (20 min)
Title: Botanical Drug Development in the Malaysian Herbal Industry: Issues, Challenges and Breakthroughs from the Perspective of a Biotechnology Company
Prof. Dr. Aman Shah B. Abdul Majid
(NatureCeuticals)
Moderator:
Assoc. Prof. Dr. Vikneswaran Murugaiyah

1045

Q & A (Invited Talks 1 to 3) (5 min)
Moderators:
– Assoc. Prof. Dr. Lim Siong Meng
– Dr. How Kang Nien
– Dr. Jonathan Lim Chee Woei
– Assoc. Prof. Dr. Vikneswaran Murugaiyah

1050

Screen Break (5 min)

1100

Parallel Sessions
(Zoom Breakout Rooms; 90 min)
– Each oral presentation (10 min)
– Q&A (5 min)

1230

Sponsored Talk (30 min)
Title: Anti-aging, disease reversal and longevity medicine in XXI century: where are we now and where are we heading to
Dr. Dmytro Klokol
(European Wellness International Group)

1300

Lunch Break (90 min)
e-Poster Viewing & Judging
Interaction with Sponsors

AREA 2: CELL THERAPY

1430

Plenary Talk 3 (30 min)
Title: Regenerating tissues … cell by cell!
Prof. Dr. John Rasko
(University of Sydney, Australia)
Moderator: Assoc. Prof. Dr. Rajesh Ramasamy

1500

Invited Talk 4 (20 min)
Title: Precision in Regenerative Medicine: Targeted Organ Specific Precursor/Progenitor Stem Cells and Peptides
Prof. Dato’ Sri Mike Chan
(European Wellness, Malaysia)
Moderator: Assoc. Prof. Dr. Rajesh Ramasamy

1520

Invited Talk 5 (20 min)
Title: An Overall Perspective on Stem Cell Applications in Musculoskeletal Sciences
Prof. Dr. Tunku Kamarul Zaman bin Tunku Zainol Abidin
(Universiti Sains Malaysia, Malaysia)
Moderator: Assoc. Prof. Dr. Rajesh Ramasamy

1540

Q & A (Invited Talks 4 to 5) (5 min)
Moderator: Assoc. Prof. Dr. Rajesh Ramasamy

1545

Screen Break (15 min)

1600

Parallel Sessions
(Zoom Breakout Rooms; 90 min)
– Each oral presentation (10 min)
– Q&A (5 min)

1745

e-Poster Viewing & Judging

1830

The End (Day 1)



 

Conference Day 2 (9th December 2021)

AREA 3: MENTAL HEALTH / NEURODEGENERATION

0830

Plenary Talk 4 (30 min)
Title: Advances in drug delivery
Prof. Dr. Edward W. Boyer
(Harvard Medical School / Ohio State University, United States)
Moderator: Assoc. Prof. Dr. Baharudin Ibrahim

0900

Invited Talk 6 (20 min)
Title: Understanding the role of GBA in Parkinson’s disease
Prof. Dr. Martin Kennedy
(University of Otago, New Zealand)
Moderator: Dr. Chua Eng Wee

0920

Screen Break (10 min)

0930

Invited Talk 7 (20 min)
Title: Opportunities and Challenges of Using Real-world Evidence in Kratom Drug Development
Prof Dr. Vicknasingam Balasingam Kasinather
(Centre for Drug Research, Malaysia)
Moderator: Assoc. Prof. Dr. Zurina Hassan

0950

Invited Talk 8 (20 min)
Title: A novel animal model of Alzheimer’s Disease
Prof. Dr. George Augustine
(Nanyang Technological University, Singapore)
Moderator: Assoc. Prof. Dr. Patrick Nwwabueze Okechukwu

1010

Q & A (Invited Talks 6 to 8) (10 min)
Moderators:
Dr. Chua Eng Wee
Assoc. Prof. Dr. Zurina Hassan
Assoc. Prof. Dr. Patrick Nwwabueze Okechukwu

1020

Screen Break (10 min)

1030

Parallel Sessions
(Zoom Breakout Rooms; 90 min)
– Each oral presentation (10 min)
– Q&A (5 min)

1200

Screen Break (10 min)

1210

Sponsored Talk (30 min)
Title: Measuring metabolic flux with cellular and molecular resolution: combining seahorse XF and LC/MS technologies for comprehensive cellular analyses
Dr. Genevieve Van de Bittner
(Agilent Technologies, Inc.)

1240

Lunch Break (90 min)
e-Poster Viewing & Judging
Interaction with Sponsors

AREA 4: MICROBIOME THERAPY

1415

Plenary Talk 5 (30 min)
Title: Therapeutic applications from the human gastrointestinal microbiome
Dr. Samuel Forster
(Hudson Institute of Medical Research, Australia)
Moderator: Prof. Dr. Kalavathy Ramasamy

1445

Invited Talk 9 (30 min)
Title: Translating research into clinical practice in chronic colitis to colorectal cancer model
Prof. Dr. Raja Affendi Raja Ali
(UKM, Malaysia)
Moderator: Assoc. Prof. Dr. Leslie Than Thian Lung

1505

Invited Talk 10 (20 min)
Title: The gut microbiome: Faecal Microbiome Transplant and beyond
Adj Assoc. Prof Dr. David Ong Eng Hui
(Asian Microbiome Library, Singapore/ Department of Medicine, National University of Singapore)
Moderator: Dr. Normala Abd Latip

1525

Q & A (Invited Talks 9 to 10) (10 min)

1535

Screen Break (5 min)

1540

World Café
(Zoom Breakout Rooms – 30 min)

1610

Screen Break (5 min)

1615

Closing Ceremony

1645

The End (Day 2)




* Disclaimer: All are subject to change

Big Data: Principal Component Analysis (PCA) & Partial Least Square (PLA) Analysis Using SIMCA 

Demonstrators/ Speakers:

  1. Assoc. Prof. Dr. Baharudin Ibrahim (UM)
  2. Dr. Fatimatuzzahra Abdul Aziz (USM)
  3. Mr. Abdulkader Ahmad Bawadikji (USM)

Venue: Online platform via Zoom

Synopsis:

This multivariate data analysis (MVA) course will provide the participants with the basics and advanced knowledge on Principal Component Analysis (PCA) and Partial Least Square Analysis (PLS). The course focuses on the use of these important statistical methods in developing and validating questionnaire and identifying crucial variables/metabolites out of thousands from human and plant samples. Hands-on training and practical applications using SPSS and SIMCA will also be provided.

The workshop will cover:

Principal Component Analysis (PCA):

  • Principles Theory of PCA
  • Multivariate data analysis
  • Score Plot and Loading Plot
  • Detecting outliers in PCA
  • Fitting and Analyzing PCA models
  • Interpreting PCA models
  • Questionnaire development
  • Reliability analysis
  • Metabolomics/Chemometrics
  • Receiver operating characteristic (ROC) curve

Partial Least Square (PLS):

  • Principles Theory of PLS
  • Interpretation of variable influence
  • Model validity and cross-validation
  • Response permutation test
  • Training-test validation
  • Metabolomics/Chemometrics
  • Partial least square discriminant analysis (PLS-DA)
  • Introduction to orthogonal partial least square (OPLS) and
    orthogonal partial least square discriminant analysis (OPLS-DA)

Fee: RM 100 (Free when you register as a delegate for ICDDTM’21 event)

Click here to register and attend ICDDTM’21 event: https://icddtm21.macr-cancer.org/registration/

Click here to register and attend for this workshop only: https://forms.gle/GM9KdMdqnfWPpv3a8

 

Conducting A Pharmacometric-Based Study 101

Demonstrators/ Speakers: 

  • Dr. Hadzliana Zainal (USM)
  • Dr. Sabariah Noor Harun (USM)
  • Dr. Siti Maisharah Sheikh Ghadzi (USM)

Venue: Online platform via Zoom

Synopsis:

This workshop is designed to impart the skills on both theoretical and practical aspects of the pharmacometric approach.The workshop content is provided as a combination of lectures, review of data, example of codes, and data analysis results, in addition to hands-on exercises. Following the workshop, the participant should be able to understand the conceptual basis and rationale for the population approach to pharmacometric-based study, where and when population methods may be optimally applied and the basic understanding to the format for fundamental NONMEM® datasets.

The workshop will cover:

  • Introduction to pharmacometric-based study
  • Non-linear fixed effect modeling
  • Sources of data and types of parameters
  • Sampling technique and data collection
  • Hands-on case studies

Fee: RM 100 (Free when you register as a delegate for ICDDTM’21 event)

Click here to register and attend ICDDTM’21 event: https://icddtm21.macr-cancer.org/registration/

Click here to register and attend for this workshop only: https://forms.gle/GM9KdMdqnfWPpv3a8

A Painless Way of Analysing Next-Generation Sequencing Data

Demonstrators/ Speakers: 

  • Dr. Chua Eng Wee (UKM)
  • Dr. Norfarhan Bt Mohd Assa`Ad (UKM)
  • Dr. Shairah Bt Abdul Razak (UKM)

Venue: Online platform via Zoom

Synopsis:

Recent years have seen a surge in the use of next-generation sequencing (NGS) for examining the genetic basis of complex diseases and drug response. However, analysing NGS data can be challenging, as many of the software tools typically require the users to have a basic grasp of command-line (or Unix) operations and programming languages. This one-day workshop is intended for those who are new to NGS and looking for a painless way to analyse NGS data in a non-Unix environment. As such, this workshop is suitable for students and researchers who are working in the fields of pharmacogenomics, cancer genomics, drug discovery, biomedicine, life science, and computational biology, or those who wish to work at centres for genomic or translational medicine. Our main objective is to equip the participants with the skills necessary for translating genomic data into meaningful functional annotations. Throughout the workshop, the participants will be taught how to run NGS analyses on a user-friendly web-based application, Galaxy, that is designed for scientists with little proficiency in bioinformatics.

The workshop will cover the following:

  • Utility and limitations of NGS in pinpointing genotype-phenotype associations.
  • Basic structures of the data files in NGS including BED, BAM, SAM, and VCF.
  • Introduction to the basic workflow of analysing NGS data, including checking data quality, sequence alignment, variant calling, and selecting high-confidence variants and gauging their functional relevance.
  • Hands-on sessions using real NGS data sets and a web-based application, Galaxy.

Fee: RM 100 (Free when you register as a delegate for ICDDTM’21 event)

Click here to register and attend ICDDTM’21 event: https://icddtm21.macr-cancer.org/registration/

Click here to register and attend for this workshop only: https://forms.gle/GM9KdMdqnfWPpv3a8

Stem Cell-Based Therapy

Demonstrators/ Speakers: 

  • Dr. Ren Xi (Charlie) (Cernegie Mellon University)
  • Dr. Kenji Miki (Havard Medical School)
  • Dr. Aizizah Ab. Ghani (MOH)
  • Mr. Chew Chun Keat (MOH)
  • Dr. Zou Yu (Thermo Fisher)
  • Dr. Xie Wei (Thermo Fisher)

Venue: Online platform via Webex

Synopsis:

In this pre-conference workshop, we are delighted to have the representative from National Pharmaceutical Regulatory Agency (NPRA) to walk us through the current guidelines for cell and gene therapy product. We have also invited Clinical Research Center (CRC), Ministry of Health Malaysia to speak on their experience to bring novel drugs to phase 1 clinical trial and the progress in Malaysia thus far. The session will be followed by lectures from eminent speakers to discuss the present applications of induced pluripotent stem cells, and the introduction to the cell reprogramming workflow which covers end-to-end solutions including: reprogramming, characterization, expansion, genome editing, differentiation & banking, of which the latter is supported by Thermo Fisher Scientific. Interactive fun games and quizzes will also be provided during the above programs with many prizes to be won. At the end of the workshop, participants will stand a chance to take part in a lucky draw and win a prize.

Fee: RM 100 (Free when you register as a delegate for ICDDTM’21 event)

Click here to register and attend ICDDTM’21 event: https://icddtm21.macr-cancer.org/registration/

Click here to register and attend for this workshop only: https://forms.gle/GM9KdMdqnfWPpv3a8

CRISPR-Cas9 Gene Editing Technology

Demonstrators/Speakers: 

  • Dr. Saiful Effendi Syafruddin (UKM)
  • Dr. Mohamad Aimanuddin Mohtar (UKM)

Venue: Online platform via Zoom

Synopsis:

Since its successful repurposing for eukaryotic cells uses, the CRISPR gene editing technology has revolutionized and taken the field by storms. The commonly employed CRISPR system is the CRISPR-Cas9 and to date, there are a plethora of engineered Cas9 variants that enable broader applications of this technology. These applications include knocking out gene, inducing/reverting mutations, DNA fragment insertion, gene expression modulations and epigenetic modifications. Moreover, there are recently developed CRISPR-Cas9-based prime editing and base editing tools that allow precise and highly efficient single or multiple bases editing. Despite these advancements, researchers who are new or would like to utilize this technology may sometimes find that it is overwhelming, challenging and costly. Nonetheless, none of these are necessarily true, CRISPR-Cas9 is considerably a straightforward and cheap technology as long as the researchers grasp its principles and well-informed on the complete experimental workflows pertinent to their research objectives.

Therefore, this workshop is designed:

  • To introduce the CRISPR-Cas9 gene editing principles and complete experimental design/workflows.
  • To teach participants the conventional and cheaper way to perform CRISPR-Cas9 experiments
  • To provide hands-on training to the participants on the following:

– sgRNA designing

– extracting targeted genomic region information using Ensembl database

– visualizing the extracted genomic information using Snapgene Viewer software

– sgRNA cloning strategy into the expression vector of choice

  • To discuss on the applications of dead Cas9 variant. e.g., CRISPR interference/activator (CRISPRi/CRISPRa), CRISPR epigenetic modifications and Base/Prime Editing
  • To discuss on the current clinical applications and ethical issues surrounding the CRISPR gene editing technology.

Fee: RM 100 (Free when you register as a delegate for ICDDTM’21 event)

Click here to register and attend ICDDTM’21 event: https://icddtm21.macr-cancer.org/registration/

Click here to register and attend for this workshop only: https://forms.gle/GM9KdMdqnfWPpv3a8